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Lastly, we found a significant correlation between ΔCD34+ cell number and ΔPWV in HeFH subjects (rho = -0.365, p < 0.05), particularly in the low-CD34+ group (rho = -0.681, p < 0.001). This polarization was no longer observed at T2, and neither with respect to controls. Dividing HeFH subjects into two groups of high- and low-CD34+ cell count, CD34+CPCs appeared to be polarized with a significant difference between the two groups (1.2 (0.46) vs. PWV was significantly reduced at T1 (ΔPWV - 14.8%, p < 0.001 vs. RESULTS: At T1, the median value of CD34+ cells was not significantly different between HeFH subjects and controls, and the same result was obtained at T2.
Valentina posterino plus#
Lipid profile and PWV were evaluated at baseline (T0), 6 months after intensive lipid lowering strategy (statin plus ezetimibe, T1), and after 6 months of optimized therapy with PCSK9-i (T2) CD34+ cell count was reported at T1 and T2. METHODS: We determined CD34+ cell count and its change after PCSK9-i in 30 selected HeFH subjects and 30 healthy controls.
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We aimed to evaluate the effects of PCSK9 inhibitors (PCSK9-i) on CD34+CPCs and pulse wave velocity (PWV) in a cohort of heterozygous familial hypercholesterolemia (HeFH) subjects. Dyslipidemic subjects seemed to have reduced CD34+CPCs, and statin therapy appeared to restore their levels. BACKGROUND: Circulating CD34+ progenitor cells (CD34+CPCs) are characterized by pronounced tissue regeneration activity.